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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VCP All Species: 35.45
Human Site: S748 Identified Species: 65
UniProt: P55072 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55072 NP_009057.1 806 89322 S748 R F A R R S V S D N D I R K Y
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_852626 806 89284 S748 R F A R R S V S D N D I R K Y
Cat Felis silvestris
Mouse Mus musculus Q3UMC0 893 97237 A834 Q T D T Y S G A E I I A V C K
Rat Rattus norvegicus P46462 806 89330 S748 R F A R R S V S D N D I R K Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520419 805 89553 S747 R F A R R S V S D N D I R K Y
Chicken Gallus gallus NP_001038129 806 89306 S748 R F A R R S V S D N D I R K Y
Frog Xenopus laevis P23787 805 89193 S748 R F A R R S V S D N D I R K Y
Zebra Danio Brachydanio rerio Q7ZU99 806 89405 S748 R F A R R S V S D N D I R K Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KN62 801 88841 R743 E A M K F A R R S V S D N D I
Honey Bee Apis mellifera XP_392892 800 88877 A741 F E E A M R F A R R S V S D N
Nematode Worm Caenorhab. elegans P54812 810 89622 A752 F E E A M K F A R R S V T D N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LZF6 810 89940 S752 K Y A R R S V S D A D I R K Y
Baker's Yeast Sacchar. cerevisiae P25694 835 91977 S770 K T A K R S V S D A E L R R Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 99.8 N.A. 38.5 99.8 N.A. 97.8 99 96.6 96.7 N.A. 83.1 83.6 78.7 N.A.
Protein Similarity: 100 N.A. N.A. 99.8 N.A. 57.1 100 N.A. 98.3 99.7 98.8 98.7 N.A. 92 93 89.2 N.A.
P-Site Identity: 100 N.A. N.A. 100 N.A. 6.6 100 N.A. 100 100 100 100 N.A. 0 0 0 N.A.
P-Site Similarity: 100 N.A. N.A. 100 N.A. 26.6 100 N.A. 100 100 100 100 N.A. 13.3 13.3 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 77.1 67.5 N.A.
Protein Similarity: N.A. N.A. N.A. 87.6 83.2 N.A.
P-Site Identity: N.A. N.A. N.A. 80 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 93.3 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 70 16 0 8 0 24 0 16 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 8 0 0 0 0 0 70 0 62 8 0 24 0 % D
% Glu: 8 16 16 0 0 0 0 0 8 0 8 0 0 0 0 % E
% Phe: 16 54 0 0 8 0 16 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 8 8 62 0 0 8 % I
% Lys: 16 0 0 16 0 8 0 0 0 0 0 0 0 62 8 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % L
% Met: 0 0 8 0 16 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 54 0 0 8 0 16 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 54 0 0 62 70 8 8 8 16 16 0 0 70 8 0 % R
% Ser: 0 0 0 0 0 77 0 70 8 0 24 0 8 0 0 % S
% Thr: 0 16 0 8 0 0 0 0 0 0 0 0 8 0 0 % T
% Val: 0 0 0 0 0 0 70 0 0 8 0 16 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 70 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _